Beneficial Effect of Substitution of Sesame Oil on Hepatic Redox Status and Lipid Parameters in Streptozotocin Diabetic Rats

Sesame oil is being used a sole edible oil in South India. The aim of present study was to monitor the influence of sesame oil on blood glucose, and lipid peroxidation, antioxidants and lipid profile in the liver of control and streptozotocin (STZ) diabetic rats (Fifteen-week old Albino Wistar rats). Diabetes was induced in adult female albino Wistar rats weighing 180200 g by administration of STZ (40 mg/kg of body weight) intraperitonially. Both control and diabetic rats were fed with a commercial diet containing 2% oil supplemented with 6% sesame oil for 42 days. Diabetic rats had elevated levels of blood glucose (322.61 ± 9.49 mg/dL), thiobarbituric acid-reactive substances (TBARS), and lipid hydroperoxides (LH) and decreased activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). When diabetic rats fed with sesame oil, were compared with diabetic rats, a significant reduction in levels of blood glucose (222.02 ± 8.27 mg/dL), TBARS, LP, and an elevation in SOD, CAT and GPx, were observed. Thus, sesame oil consumption beneficially influences blood glucose, lipid peroxidation, antioxidants and lipid parameters in diabetic rats.